Cortical Reorganization for Response Regulation With Unilateral Thalamic Stroke Detected by Functional MRI
Kenneth S. L. Yuen, MPhil1,
Tatia M. C. Lee, PhD1*,
Yau-Yau Wai, MD2,
Ho-Ling Liu, PhD2,
Edith N. H. Mok, PhD3,
Leonard S. W. Li, MBBS4,
Chetwyn C. H. Chan, PhD5
1 Dept of Psychology, University of Hong Kong, and Institute of Clinical Neuropsychology, The University of Hong Kong & MacLehose Medical Rehabilitation Centre
2 Dept of Medical Imaging and Radiological Sciences, Chang Gung University, and MRI Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
3 Institute of Clinical Neuropsychology, The University of Hong Kong & MacLehose Medical Rehabilitation Centre
4 Institute of Clinical Neuropsychology, The University of Hong Kong & MacLehose Medical Rehabilitation Centre, and Dept of Medicine, The University of Hong Kong
5 Applied Cognitive Neuroscience Laboratory, Dept of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
* To whom correspondence should be addressed. E-mail: tmclee{at}hkusua.hku.hk.
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Abstract |
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To understand neural reorganization of response regulation after stroke, a 54-year-old woman with a chronic left thalamic stroke performed a task requiring decisions about the directionality of an arrow during cerebral functional magnetic resonance imaging. Her performance was compared to 13 matched healthy control subjects. Her behavioral responses were slower but as accurate. Bilateral frontal activations were observed in the right medial frontal gyrus (BA 9), left superior frontal gyrus (BA 45), and left frontal rectus gyrus (BA 11). Activation in the right medial frontal gyrus, along with activity in close proximity to the anterior cingulate cortex, was observed, which may reflect reorganization of activity after the loss of function of the anterior cingulate cortex.
