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Cortical Reorganization for Response Regulation With Unilateral Thalamic Stroke Detected by Functional MRI

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

Tatia M. C. Lee, PhD

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong, tmclee{at}hkusua.hku.hk

Yau-Yau Wai, MD

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

Ho-Ling Liu, PhD

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

Edith N. H. Mok, PhD

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

Leonard S. W. Li, MBBS

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

Chetwyn C. H. Chan, PhD

K610, Laboratory of Neuropsychology, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong

To understand neural reorganization of response regulation after stroke, a 54-year-old woman with a chronic left thalamic stroke performed a task requiring decisions about the directionality of an arrow during cerebral functional magnetic resonance imaging. Her performance was compared to 13 matched healthy control subjects. Her behavioral responses were slower but as accurate. Bilateral frontal activations were observed in the right medial frontal gyrus (BA 9), left superior frontal gyrus (BA 45), and left frontal rectus gyrus (BA 11). Activation in the right medial frontal gyrus, along with activity in close proximity to the anterior cingulate cortex, was observed, which may reflect reorganization of activity after the loss of function of the anterior cingulate cortex.

Key Words: Neuroplasticity • Cortical recovery • Response regulation • Inhibition • fMRI • Neural reorganization.

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This version was published on October 1, 2007

Neurorehabilitation and Neural Repair, Vol. 21, No. 5, 467-471 (2007)
DOI: 10.1177/1545968306298415


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yuen, K. S. L. Articles by Chan, C. C. H. Search for Related Content PubMed PubMed Citation Articles by Yuen, K. S. L. Articles by Chan, C. C. H. Social Bookmarking                         What's this?