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Neuroimaging Patterns Associated with Motor Control in Traumatic Brain Injury

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany, Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany, martin.lotze{at}uni-tuebingen.de

W. Grodd, MD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

F. A. Rodden, MD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

E. Gut, MD

Lurija-Institute for Rehabilitation Sciences and Health Research at the University of Konstanz, Kliniken Schmieder, Allensbach, Germany

P. W. Schönle, MD, PhD

Lurija-Institute for Rehabilitation Sciences and Health Research at the University of Konstanz, Kliniken Schmieder, Allensbach, Germany

B. Kardatzki, PhD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

L. G. Cohen, MD

Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

Objective. To determine if patients with traumatic brain injury (TBI) and motor deficits show differences in functional activation maps during repetitive hand movements relative to healthy controls. Are there predictors for motor outcome in the functional maps of these patients? Methods. In an exploratory cross-sectional study, functional magnetic resonance imaging (fMRI) was used to study the blood-oxygenation-level-dependent (BOLD) response in cortical motor areas of 34 patients suffering from moderate motor deficits after TBI as they performed unilateral fist-clenching motions. Twelve of these patients with unilateral motor deficits were studied 3 months after TBI and a 2nd time approximately 4 months later. Results. Compared to age-matched, healthy controls performing the same task, TBI patients showed diminished fMRI-signal change in the primary sensorimotor cortex contralateral to the moving hand (cSM1), the contralateral dorsal premotor cortex, and bilaterally in the supplementary motor areas (SMAs). Clinical impairment and the magnitude of the fMRI-signal change in cSM1 and SMA were negatively correlated. Patients with poor and good motor recovery showed comparable motor impairment at baseline. Only patients who evolved to "poor clinical outcome" had decreased fMRI-signal change in the cSM1 during baseline. Conclusions. These observations raise the hypothesis that the magnitude of the fMRI-signal change in the cSM1 region could have prognostic value in the evaluation of patients with TBI.

Key Words: TBI • fMRI • Primary motor cortex • Outcome

References

• Asikainen I, Kaste M, Sarna S. Predicting late outcome for patients with traumatic brain injury referred to a rehabilitation program: a study of 508 Finnish patients 5 years or more after injury. Brain Inj 1998;12:95-107.[CrossRef][Medline] [Order article via Infotrieve]
• Friedman SD, Brooks WM, Jung RE, Hart BL, Yeo RA. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury. Am J Neuroradiol 1998;19: 1879-1885.[Abstract]
• van der Naalt J, Hew JM, van Zomeren AH, Sluiter WJ, Minderhoud JM. Computed tomography and magnetic resonance imaging in mild to moderate head injury: early and late imaging related to outcome. Ann Neurol 1999;46:70-78.[CrossRef][Medline] [Order article via Infotrieve]
• Weiller C. Imaging recovery from stroke. Exp Brain Res 1998;123:13-17.[CrossRef][Medline] [Order article via Infotrieve]
• Wexler BE, Fulbright RK, Lacadie CM, et al. 1997. An fMRI study of the human cortical motor system response to increasing functional demands. Magn Reson Imaging 15:385-396.[CrossRef][Medline] [Order article via Infotrieve]
• Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97-113.[CrossRef][Medline] [Order article via Infotrieve]
• Bobath B. Treatment of adult hemiplegia. Physiotherapy 1977;63:310-313.[Medline] [Order article via Infotrieve]
• Adams RJ, Kimford JM, Kapil DS, Grotta JC, Thomson DS. Graded neurologic scale for use in acute hemispheric stroke treatment protocols. Stroke 1987;18:665-669.[Abstract/Free Full Text]
• Janda V, ed. Muskelfunktionsdiagnostik. New York: Ullstein Mosby; 1993.
• Parizel PM, Öszarlak Ö, Van Goethem JW, et al. Imaging findings in diffuse axonal injury after closed head trauma. Eur Radiol 1998;8:960-965.[CrossRef][Medline] [Order article via Infotrieve]
• Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme; 1988.
• Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of outcome after stroke: a cross-sectional fMRI study. Brain 2003;126:1430-1448.[Abstract/Free Full Text]
• Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 2003;126:2476-2496.[Abstract/Free Full Text]
• Pariente J, Loubinoux I, Carel C, et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol 2001;50:718-729.[CrossRef][Medline] [Order article via Infotrieve]
• Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RJS. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 1995;2:189-210.[CrossRef]
• Brett M, Leff AP, Rorden C, Ashburner J. Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 2001;14:486-500.[CrossRef][Medline] [Order article via Infotrieve]
• Waldvogel D, van Gelderen P, Immisch I, Pfeiffer C, Hallett M. The variability of serial fMRI data: correlation between a visual and a motor task. Neuroreport 2000;11:3843-3847.[Medline] [Order article via Infotrieve]
• Weiller C, Isensee Ch, Rijntjes M, et al. Recovery from Wernicke’s aphasia: a positron emission tomographic study. Ann Neurol 1995;37:723-732.[CrossRef][Medline] [Order article via Infotrieve]
• Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002;15:273-289.[CrossRef][Medline] [Order article via Infotrieve]
• Katz DI, Alexander MP, Klein RB. Recovery of arm function in patients with paresis after traumatic brain injury. Arch Phys Med Rehabil 1998;79:488-493.[Medline] [Order article via Infotrieve]
• Shelton FN, Reding MJ. Effect of lesion location on upper limb motor recovery after stroke. Stroke 2001;32:107-112.[Abstract/Free Full Text]
• Corrigan JD, Smith-Knapp K, Granger CV. Outcomes in the first 5 years after traumatic brain injury. Arch Phys Med Rehabil 1998;79:298-305.[CrossRef][Medline] [Order article via Infotrieve]
• Binkofsky F, Seitz RJ, Arnold S, Classen J, Benecke R, Freund HJ. Thalamic metabolism and corticospinal tract integrity determine motor recovery after stroke. Ann Neurol 1996;39:460-470.[CrossRef][Medline] [Order article via Infotrieve]
• Nelles G, Spiekermann G, Jueptner M, et al. Evolution of functional reorganization in hemiplegic stroke: a serial positron emission tomographic activation study. Ann Neurol 1999;46:901-909.[CrossRef][Medline] [Order article via Infotrieve]
• Turton A, Wroe S, Trepte N, Fraser C, Lemon RN. Contralateral and ipsilateral EMG responses to transcranial magnetic stimulation during recovery of arm and hand function after stroke. Electroencephalogr Clin Neurophysiol 1996;101:316-328.[CrossRef][Medline] [Order article via Infotrieve]
• Glenn TC, Kelly DF, Boscardin WJ, et al. Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab 2003;23:1239-1250.[CrossRef][Medline] [Order article via Infotrieve]
• Kastrup A, Kruger G, Neumann-Haefelin T, Glover GH, Moseley ME. Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation. Neuroimage 2002;15: 74-82.[CrossRef][Medline] [Order article via Infotrieve]

Neurorehabilitation and Neural Repair, Vol. 20, No. 1, 14-23 (2006)
DOI: 10.1177/1545968305282919


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