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Neurorehabilitation and Neural Repair
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Effectiveness of Physiotherapy, Occupational Therapy, and Speech Pathology for People with Huntington's Disease: A Systematic Review

Belinda Bilney

Meg E. Morris

Alison Perry

This review provides a summary of the current literature examining the outcomes of physiotherapy, occupational therapy, and speech pathology interventions for people with Huntington's disease. The literature was retrieved via a systematic search using a combination of key words that included Huntington's disease, physiotherapy, occupational therapy, and speech pathology. The electronic databases for Medline, Embase, CINAHL, Cochrane Controlled Trials Register, and PEDro were searched up to May 2002. Articles meeting the review criteria were graded for study type and rated for quality using checklists to assess study validity and methodology. The majority of articles that examined therapy outcomes for people with Huntington's disease were derived from observational studies of low methodological quality. A low level of evidence exists to support the use of physiotherapy for addressing impairments of balance, muscle strength, and flexibility. There was a small amount of evidence to support the use of speech pathology for the management of eating and swallowing disorders. The current evidence is insufficient to make strong recommendations regarding the usefulness of physiotherapy, occupational therapy, or speech pathology for people with Huntington's disease. There is further need for therapy outcomes research in Huntington's disease so that clinicians may use evidence-based practice to assist clinical decision making.

Key Words: Huntington's disease • Speech-language pathology • Occupational therapy • Physiotherapy

References

  • 1. Gusella JF, MacDonald ME, Ambrose CM, Duyao MP. Molecular genetics of Huntington's disease. Arch Neurol1993; 50(11): 1157-63.[Abstract/Free Full Text]
  • 2.Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell1993; 72: 971-83.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 3. Albin RL, Reiner A, Anderson KD, et al. Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease. Ann Neurol1992; 31(4): 425-30.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 4. Albin RL. Selective neurodegeneration in Huntington's disease. Ann Neurol1995; 38: 835-6.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 5. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr.Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol1985; 44(6): 559-77.[Web of Science][Medline] [Order article via Infotrieve]
  • 6. Vonsattel JP. Neuropathology of Huntington's disease. In: Joseph AB, Young RR, eds. Movement disorders in neurology and neuropsychiatry. Cambridge (UK): Blackwell Scientific; 1992: 186-94.
  • 7. Rosenblatt A, Brinkman RR, Liang KY, et al. Familial influence on age of onset among siblings with Huntington disease. Am J Med Genet2001; 105(5): 399-403.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 8. Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet1993; 4(4): 387-92.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 9. Kirkwood SC, Su JL, Conneally PM, Foroud T. Progression of symptoms in the early and middle stages of Huntington disease. Arch Neurol2001; 58(2): 273-8.[Abstract/Free Full Text]
  • 10. Roos RAC, Hermans J, Vegter-van der Vlis M, Ommen GJB, Bruyn GW. Duration of illness in Huntington's disease is not related to age at onset. J Neurol Neurosurg Psychiatry1993; 56: 98-100.[Abstract/Free Full Text]
  • 11. Marder K, Zhao H, Myers RH, et al. Rate of functional decline in Huntington's disease. Huntington Study Group [published erratum appears in Neurology 2000 Apr 25; 54(8): 1712]. Neurology2000; 54(2): 452-8.[Abstract/Free Full Text]
  • 12. Nance MA, Myers RH. 2001. Juvenille onset Huntington's disease-clinical and research perspectives. Ment Retard Dev Disabil Res Rev2001; 7(3): 153-7.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 13. Huttunen J, Hömberg V. EMG responses in leg muscles to postural perturbations in Huntington's disease. J Neurol1990; 53: 55-62.[CrossRef][Web of Science]
  • 14. Tian JR, Herdman SJ, Zee DS, Folstein SE. Postural control in Huntington's disease (HD). Acta Oto-Laryngologica-Suppl1991; 481: 333-6.
  • 15. Tian JR, Herdman SJ, Zee DS, Folstein SE. Postural stability in patients with Huntington's disease. Neurology1992; 42: 1232-8.[Abstract/Free Full Text]
  • 16. Heathfield KWG. Huntington's chorea. Investigation into the prevelance of the disease in the area covered by the North East Metropolitan Regional Hospital Board. Brain1967; 90: 203-33.[Free Full Text]
  • 17. Koller WC, Trimble J. The gait abnormality of Huntington's disease. Neurology1985; 35(10): 1450-4.[Abstract/Free Full Text]
  • 18. Folstein S. Huntington's disease. Baltimore (MD): John Hopkins University Press; 1989.
  • 19. Gordon AM, Quinn L, Reilmann R, Marder K. Coordination of prehensile forces during precision grip in Huntington's disease. Exp Neurol2000; 163(1): 136-48.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 20. Phillips JG, Bradshaw JL, Chiu E, Bradshaw JA. Characteristics of handwriting of patients with Huntington's Disease. Mov Disord1994; 9: 521-30.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 21. Thompson JC, Snowden JS, Craufurd D, Neary D. Behavior in Huntington's disease: dissociating cognition-based and mood-based changes. J Neuropsychiatry Clin Neurosci2002; 14(1): 37-43.[Abstract/Free Full Text]
  • 22. Snowden J, Craufurd D, Griffiths H, Thompson J, Neary D. Longitudinal evaluation of cognitive disorder in Huntington disease. J Int Neuropsychol Soc2001; 7(1): 33-44.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 23. Georgiou N, Bradshaw JL, Phillips JG, Chiu E. Effect of directed attention in Huntington's disease. J Clin Exp Neuropsychol1997; 19(3): 367-77.[Web of Science][Medline] [Order article via Infotrieve]
  • 24. Murray LL. Spoken language production in Huntington's and Parkinson's diseases. J Speech Lang Hear Res2000; 43(6): 1350-66.[Abstract/Free Full Text]
  • 25. Chua P, Chiu E. Huntington's disease. In: O'Brien J, Ames D, Burns A, eds. Dementia. London: Arnold; 2000: 827-43.
  • 26. Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychaitric aspects of Huntington's disease. J Neurol Neurosurg Psychiatry2001; 71(3): 310-14.[Abstract/Free Full Text]
  • 27. Rosenblatt A, Ranen N, Nance MA, Paulsen J. A physician's guide to the management of Huntington's disease. 2nd ed.New York: Huntington's Disease Society of America; 1999.
  • 28. Murray LL, Lenz LP. Productive syntax abilities in Huntington's and Parkinson's diseases. Brain Cogn2001; 46(1-2): 213-19.[Web of Science][Medline] [Order article via Infotrieve]
  • 29. Logemann JA. Dysphagia in movement disorders. Adv Neurol1988; 49: 307-16.[Medline] [Order article via Infotrieve]
  • 30. Miller RM, Langmore SE. Treatment efficacy for adults with oropharyngeal dysphagia. Arch Phys Med Rehabil1994; 75: 1256-62.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 31. Hunt VP, Walker FO. Dysphagia in Huntington's disease. J Neurosci Nurs1989; 21(2): 92-5.[Medline] [Order article via Infotrieve]
  • 32. Shakespeare J, Anderson J. Huntington's disease-falling through the net. Health Trends1993; 25(1): 19-23.[Medline] [Order article via Infotrieve]
  • 33. Skirton H, Glendinning N. Using research to develop care for patients with Huntington's disease. Br J Nurs1997; 6(2): 83-90.[Medline] [Order article via Infotrieve]
  • 34. Carr J, Shepherd R. Neurological rehabilitation: Optimizing motor peformance. Oxford: Butterworths-Heinemann; 1998.
  • 35. Umphred DA, ed. Neurological rehabilitation. 3rd ed.St Louis (MO): Mosby-Year Book; 1995.
  • 36. Churchyard AJ, Morris M, Georgiou N, Chiu E, Cooper R, Iansek R. Gait dysfunction in Huntington's disease: parkinsonism and a disorder of timing. Implications for movement rehabilitation. Adv Neurol2001; 87: 375-85.[Web of Science][Medline] [Order article via Infotrieve]
  • 37. Peacock IW. A physical therapy program for Huntington's disease patients. Clinic Manag Phys Ther1987; 7(1): 22-3, 34.
  • 38. Imbriglio S, Peacock LW. Huntington's disease at mid-stage. Clin Manage1992; 12(5): 62-72.
  • 39. Huntington Disease Society of America. Physical and occupational therapy for Huntington's disease. Retrieved January 23, 2002, from http://www.had.org/edu/therapy.html
  • 40. Quinn L, Reilmann R, Marder K, Gordon AM. Altered movement trajectories and force control during object transport in Huntington's disease. Mov Disord2001; 16(3): 469-80.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 41. Chiu E, Teltscher B, eds. Handbook for caring in Huntington's disease. Melbourne: Huntington's Disease Clinic; 1985.
  • 42. Trombly CA, ed. Occupational therapy for physical dysfunction. 4th ed.Baltimore (MD): Williams & Wilkins; 1995.
  • 43. Rebok GW, Bylsma FW, Keyl PM, Brandt J, Folstein SE. Automobile driving in Huntington's disease. Mov Disord1995; 10(6): 778-87.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 44. Klasner ER. Managing swallowing difficulties associated with Huntington's disease. Cambridge (ON): Huntington Society of Canada; 1990.
  • 45. Klasner ER. Managing the communication and speech difficulties associated with Huntington's disease. Cambridge (ON): Huntington Society of Canada; 1990.
  • 46. Korer J, Fitzsimmons JS. The effect of Huntington's Chorea on family life. Br J Soc Work1985; 15: 581-97.[Abstract/Free Full Text]
  • 47. Khan KS, ter Riet G, Popay J, Nixon J, Kleijnen J. Undertaking systematic reviews of research on effectiveness. CRD's guidance for those carrying out or commissioning reviews. York (UK): University of York; 2001.
  • 48. United States Department of Health and Human Services. Agency for Health Care Policy and Research. Acute pain management: operative or medical procedures and trauma. Rockville, MD: AHCPR; 1993: 107. (Clinical practice guideline No 1, AHCPR publication No 92-0023.)
  • 49. Binswanger C. Physical therapy in Huntington disease. Arch Phys Med Rehabil1980; 61(3): 148.
  • 50. Lavers A. An account of a weekly activity group with Huntington's chorea patients on a long stay ward. Occup Ther1981; 44: 387-92.
  • 51. Sheaff F. Hydrotherapy in Huntington's disease. Nurs Times1990; 86(4): 46-9.
  • 52. Mason J, Andrews K, Wilson E. Late stage Huntington's disease: effect of treating specific disabilities. Br J Occup Ther1991; 54(1): 4-8.
  • 53. Di Scipio WJ, Hannesson ME. Neuromuscular facilitation in the treatment of Huntington's chorea. Behav Neuropsychiatry1971; 2(9-10): 13-14.
  • 54. Rood MS. Neurophysiological mechanism utilized in the treatment of neuromuscular dysfunction. Am J Occup Ther1956; 10: 220-5.
  • 55. Kagel MC, Leopold NA. Dysphagia in Huntington's disease: a 16-year retrospective. Dysphagia1992; 7(2): 106-14.[CrossRef][Medline] [Order article via Infotrieve]
  • 56. Leopold NA, Kagel MC. Dysphagia in Huntington's disease. Arch Neurol1985; 42(1): 57-60.[Abstract/Free Full Text]
  • 57. Klasner ER, Yorkston KM. Linguistic and cognitive supplementation strategies as augmentatative and alternative communication techniques in Huntington's disease: case report. Augment Altern Commun2001; 17(September): 154-60.[CrossRef]
  • 58. Frank EM, McDade HL, Scott WK. Naming in dementia secondary to Parkinson's, Huntington's, and Alzheimer's diseases. J Commun Disord1996; 29(3): 183-97.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 59. Hertrich I, Ackermann H. Acoustic analysis of speech timing in Huntington's disease. Brain Lang1994; 47(2): 182-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 60. Hodges JR, Salmon DP, Butters N. Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study. J Neurol Neurosurg Psychiatry1990; 53(12): 1089-95.[Abstract/Free Full Text]
  • 61. Ludlow CL, Connor NP, Bassich CJ. Speech timing in Parkinson's and Huntington's disease. Brain Lang1987; 32(2): 195-214.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 62. Ozsancak C, Auzou P, Jan M, Hannequin D. Measurement of voice onset time in dysarthric patients: methodological considerations. Folia Phoniatrica et Logopaedica2001; 53(1): 48-57.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 63. Podoll K, Caspary P, Lange HW, Noth J. Language functions in Huntington's disease. Brain1988; 111(Pt 6): 1475-503.[Abstract/Free Full Text]
  • 64. Speedie LJ, Brake N, Folstein SE, Bowers D, Heilman KM. Comprehension of prosody in Huntington's disease. J Neurol Neurosurg Psychiatry1990; 53(7): 607-10.[Abstract/Free Full Text]
  • 65. Troster AI, Salmon DP, McCullough D, Butters N. A comparison of the category fluency deficits associated with Alzheimer's and Huntington's disease. Brain Lang1989; 37(3): 500-13.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 66. Huntington Study Group. Unified Huntington's disease rating scale: reliability and consistency. Mov Disord1996; 11(2): 136-42.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 67. Bradshaw JL, Phillips JG, Dennis C, et al. Initiation and execution of movement sequences in those suffering from and at-risk of developing Huntington's disease. J Clin Exp Neuropsychol1992; 14(2): 179-92.[Web of Science][Medline] [Order article via Infotrieve]
  • 68. Georgiou N, Bradshaw JL, Phillips JG, Bradshaw JA, Chiu E. The Simon effect and attention deficits in Gilles de la Tourette's syndrome and Huntington's disease. Brain1995; 118: 1305-18.[Abstract/Free Full Text]
  • 69. Georgiou N, Bradshaw JL, Phillips JG, Chiu E. The effect of Huntington's disease and Gilles de la Tourette's syndrome on the ability to hold and shift attention. Neuropsychologia1996; 34(9): 843-51.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 70. Hausdorff JM, Mitchell SL, Firtion R, et al. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. J Appl Physiol1997; 82(1): 262-9.[Abstract/Free Full Text]
  • 71. Hausdorff JM, Cudkowicz ME, Firtion R, et al. Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease. Mov Disord1998; 13(3): 428-37.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 72. Enderby P. The Frenchay dysarthria assessment. London: College Hill Press; 1983.
  • 73. Folstein SE, Jensen B, Leigh RJ, Folstein MF. The measurement of abnormal movement: methods developed for Huntington's disease. Neurobehav Toxicol Teratol1983; 5: 605-9.[Web of Science][Medline] [Order article via Infotrieve]
  • 74. Hefter H, Hömberg V, Lange HW, Freund HJ. Impairment of rapid movements in Huntington's disease. Brain1987; 110: 585-612.[Abstract/Free Full Text]
  • 75. Georgiou N, Phillips JG, Bradshaw JL, Cunnington R, Chiu E. Impairments of movement kinematics in patients with Huntington's disease: a comparison with and without a concurrent task. Mov Disord1997; 12(3): 386-96.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 76. Phillips JG, Chiu E, Bradshaw JL, Iansek R. Impaired movement sequencing in patients with Huntington's disease: a kinematic analysis. Neuropsychologia1995; 33(3): 365-9.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 77. Reynolds NC Jr, Myklebust JB, Prieto TE, Myklebust BM. Analysis of gait abnormalities in Huntington disease. Arch Phys Med Rehab1999; 80(1): 59-65.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 78. Thaut MH, Miltner R, Lange HW, Hurt CP, Hoemberg V. Velocity modulation and rhythmic synchronization of gait in Huntington's disease. Mov Disorders1999; 14(5): 808-19.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 79. van Dellen A, Blakemore C, Deacon R, York D, Hannan AJ. Delaying the onset of Huntington's in mice. Nature2000; 404: 721-2.[CrossRef][Medline] [Order article via Infotrieve]
  • 80. Chalmers F. Cider with therapy... Huntington's disease. Therapy Weekly2001; 27(37): 16.

Neurorehabilitation and Neural Repair, Vol. 17, No. 1, 12-24 (2003)
DOI: 10.1177/0888439002250448
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