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Receptor Plasticity and Volume Transmission in the Brain: Emerging Concepts with Relevance to Neurologic Rehabilitation

Department of Rehabilitation Medicine, University of Wisconsin, Madison, WI, U.S.A., Departments of Physical Medicine and Rehabilitation, and Neurology (Huddinge), Karolinska Institutet, Stockholm, Sweden

Recent evidence of the plasticity of central nervous system receptors, as well as evidence for cell-to-cell communication via the extracellular fluid (volume transmission), has been selectively reviewed. The possible relevance of those mechanisms to neurologic rehabilitation has been discussed in this speculative synthesis. A model of adaptive responses to brain damage has been proposed; it includes neuronal sprouting, synaptic receptor plasticity (unmasking), and extrasynaptic receptor plasticity (volume transmission). Key Words: Receptor plasticity-Volume transmission—Neurologic rehabilitation—Unmasking—Neurotransmit— ters-Brain plasticity.

Neurorehabilitation and Neural Repair, Vol. 4, No. 3, 121-128 (1990)
DOI: 10.1177/136140969000400301


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