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Neurorehabilitation and Neural Repair
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Time Course of Functional Recovery After Stroke: The Framingham Study

Margaret Kelly-Hayes

Department of Neurology, Boston University School of Medicine

Philip A. Wolf

Department of Neurology, Boston University School of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA

Carlos S. Kase

Department of Neurology, Boston University School of Medicine

Glen E. Gresham

Department of Rehabilitation Medicine, State University of New York at Buffalo, Buffalo, NY

William B. Kannel

Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA

Ralph B. D'Agostino

Department of Mathematics, Boston University, Boston, MA, U.S.A.

The time course for functional recovery following stroke has not been well defined. To obtain an unbiased picture, we studied the pace of recovery using standardized neurological, functional, and cognitive tests in stroke survivors in the Framingham cohort over a 41/2-year period. Of 119 patients who developed new strokes, 67 survived 1 year; of these, 46 were evaluated at onset, and at 3, 6, and 12 months poststroke. Significant recovery was documented in the Barthel Index, mobility, self-care, and language. This occurred chiefly during the first 3 months, with marginal gains thereafter. Multivariate analyses revealed no differences in the pattern of recovery with regard to clinical or demographic characteristics. These data from a community-based study document improvement in physical function over a relatively short period of time after stroke onset. Focusing treatment and rehabilitation within this specific time period may enhance eventual outcome for stroke survivors. Key Words: Cerebrovascular disease—Epidemi— ology—Prognosis—Activities of daily living.

Neurorehabilitation and Neural Repair, Vol. 3, No. 2, 65-70 (1989)
DOI: 10.1177/136140968900300202
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