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Effect of Exercise Training on Walking Mobility in Multiple Sclerosis: A Meta-Analysis

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois

Robert W. Motl, PhD

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, robmotl{at}uiuc.edu

Objective. The study used meta-analytic procedures to examine the overall effect of exercise training interventions on walking mobility among individuals with multiple sclerosis. Methods. A search was conducted for published exercise training studies from 1960 to November 2007 using MEDLINE, PsychINFO, CINAHL, and Current Contents Plus. Studies were selected if they measured walking mobility, using instruments identified as acceptable walking mobility constructs and outcome measures for individuals with neurologic disorders, before and after an intervention that included exercise training. Results. Forty-two published articles were located and reviewed, and 22 provided enough data to compute effect sizes expressed as Cohen's d. Sixty-six effect sizes were retrieved from the 22 publications with 600 multiple sclerosis participants and yielded a weighted mean effect size of g = 0.19 (95% confidence interval, 0.09-0.28). There were larger effects associated with supervised exercise training ( g = 0.32), exercise programs that were less than 3 months in duration (g = 0.28), and mixed samples of relapsing-remitting and progressive multiple sclerosis (g = 0.52). Conclusions. The cumulative evidence supports that exercise training is associated with a small improvement in walking mobility among individuals with multiple sclerosis.

Key Words: Meta-Analysis • Multiple sclerosis • Rehabilitation • Mobility • Exercise

This version was published on February 1, 2009

Neurorehabilitation and Neural Repair, Vol. 23, No. 2, 108-116 (2009)
DOI: 10.1177/1545968308320641


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