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Pharmacological Modulation of Plasticity in the Human Motor Cortex

Department of Neurology, J. W. Goethe-University Frankfurt, Frankfurt am Main, Germany, u.ziemann{at}em.uni-frankfurt.de

Frank Meintzschel, MD

Department of Neurology, J. W. Goethe-University Frankfurt, Frankfurt am Main, Germany

Alexei Korchounov, MD

Department of Neurology, J. W. Goethe-University Frankfurt, Frankfurt am Main, Germany

Tihomir V. Ili, MD

Department of Neurology, J. W. Goethe-University Frankfurt, Frankfurt am Main, Germany

Ischemic cerebral stroke is the leading cause of long-term disability among adults in industrialized countries. One fundamental but still not sufficiently solved question is how to improve disability after stroke. Here, evidence will be reviewed on how pharmacological treatment modulates plasticity and learning in the intact human motor cortex. It will be argued that these data may be useful for advancing the concepts of pharmacotherapy for recovery after stroke.

Key Words: Transcranial magnetic stimulation • Motor cortex • Plasticity • Motor learning • Recovery of function after stroke

Neurorehabilitation and Neural Repair, Vol. 20, No. 2, 243-251 (2006)
DOI: 10.1177/1545968306287154


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