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Evolution of Brain Activation with Good and Poor Motor Recovery after Stroke

National Stroke Research Institute, Austin Health, Heidelberg West, Victoria, Australia, LaTrobe University, Bundoora, Victoria, Australia, lcarey{at}nsri.org.au

David F. Abbott, PhD

Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia

Gary F. Egan, PhD

Howard Florey Institute, Melbourne, Victoria, Australia

Graham J. O’Keefe, PhD

Centre for Positron Emission Tomography, Austin Health, Heidelberg West, Victoria, Australia

Graham D. Jackson, MD

Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia

Julie Bernhardt, PhD

National Stroke Research Institute, Austin Health, Heidelberg West, Victoria, Australia

Geoffrey A. Donnan, MD

National Stroke Research Institute, Austin Health, Heidelberg West, Victoria, Australia

Objective. To characterize the evolution of brain activation in stroke patients with variable motor recovery and quantify changes relative to healthy controls. Methods. Serial PET activation studies, using a simple finger-tapping task, and quantitative measures of motor performance were obtained in 9 patients (2-7 weeks poststroke and 6 months later) and compared with serial healthy volunteer data. Results. Patients with moderate impairment and good recovery (n = 5) activated the primary sensorimotor cortex (SM1) contralateral to the paretic hand moved, bilateral supplementary motor area (SMA), contralateral cingulate gyrus, and ipsilateral lateral premotor cortex. Activation in the bilateral SMA was greater at the initial study but reduced over time compared to healthy controls and poor recoverers. Patients with severe impairment and poor recovery (n =4) showed limited activation of contralateral SM1 and SMA at both studies and no significant change over time. A posterior shift in SM1 activation was evident in good and poor recoverers. Conclusions. Activation of typical motor regions and recruitment of additional sites occur subacutely poststroke, with evolution to normal patterns in moderately impaired patients who recover well. In comparison, severely impaired, poor-recovery patients show persistent, reduced activation. Dynamic changes in SMA, differentially observed in good recoverers over 6 months, highlight its importance in recovery.

Key Words: Cerebrovascular accident • Neuronal plasticity • Brain Mapping • Hand • Motor cortex

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