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Neuroimaging Patterns Associated with Motor Control in Traumatic Brain Injury

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany, Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany, martin.lotze{at}uni-tuebingen.de

W. Grodd, MD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

F. A. Rodden, MD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

E. Gut, MD

Lurija-Institute for Rehabilitation Sciences and Health Research at the University of Konstanz, Kliniken Schmieder, Allensbach, Germany

P. W. Schönle, MD, PhD

Lurija-Institute for Rehabilitation Sciences and Health Research at the University of Konstanz, Kliniken Schmieder, Allensbach, Germany

B. Kardatzki, PhD

Section Exp. MR of the CNS, Department of Neuroradiology, University of Tuebingen, Tuebingen, Germany

L. G. Cohen, MD

Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD

Objective. To determine if patients with traumatic brain injury (TBI) and motor deficits show differences in functional activation maps during repetitive hand movements relative to healthy controls. Are there predictors for motor outcome in the functional maps of these patients? Methods. In an exploratory cross-sectional study, functional magnetic resonance imaging (fMRI) was used to study the blood-oxygenation-level-dependent (BOLD) response in cortical motor areas of 34 patients suffering from moderate motor deficits after TBI as they performed unilateral fist-clenching motions. Twelve of these patients with unilateral motor deficits were studied 3 months after TBI and a 2nd time approximately 4 months later. Results. Compared to age-matched, healthy controls performing the same task, TBI patients showed diminished fMRI-signal change in the primary sensorimotor cortex contralateral to the moving hand (cSM1), the contralateral dorsal premotor cortex, and bilaterally in the supplementary motor areas (SMAs). Clinical impairment and the magnitude of the fMRI-signal change in cSM1 and SMA were negatively correlated. Patients with poor and good motor recovery showed comparable motor impairment at baseline. Only patients who evolved to "poor clinical outcome" had decreased fMRI-signal change in the cSM1 during baseline. Conclusions. These observations raise the hypothesis that the magnitude of the fMRI-signal change in the cSM1 region could have prognostic value in the evaluation of patients with TBI.

Key Words: TBI • fMRI • Primary motor cortex • Outcome

Neurorehabilitation and Neural Repair, Vol. 20, No. 1, 14-23 (2006)
DOI: 10.1177/1545968305282919


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