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Neurorehabilitation and Neural Repair
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Effects of Intravenous Physostigmine and Lecithin on Memory Loss in Multiple Sclerosis: Report of a Pilot Study

Gary J. Leo

Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, U.S.A.

Stephen M. Rao

Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, U.S.A.

This paper reports the results of a pilot study designed to assess the efficacy of intravenous physostigmine and dietary lecithin for treating memory loss in patients with multiple sclerosis (MS). Four patients with definite MS participated in a two-phase (dose-finding and crossover), double-blind clinical trial. In the dose-finding phase, all patients exhibited an improvement in verbal memory (as assessed by the Selective Reminding Test) at the highest of four doses (1.0 mg). In the double-blind, crossover phase, patients were administered placebo or physostigmine (1.0 mg). A significant improvement in verbal memory was observed in three of four patients during the drug condition. None of the patients reported significant medication side effects. This study provides preliminary evidence that cholinergic pharmacotherapy may be useful in treating memory disturbance in MS.

Key Words: Multiple sclerosis • Memory loss • Physostigmine • Lecithin.

Neurorehabilitation and Neural Repair, Vol. 2, No. 3, 123-129 (1988)
DOI: 10.1177/136140968800200305
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