This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cramer, S. C. Articles by Rosen, B. R. Search for Related Content PubMed PubMed Citation Articles by Cramer, S. C. Articles by Rosen, B. R. Social Bookmarking                         What's this?

A Functional MRI Study of Three Motor Tasks in the Evaluation of Stroke Recovery

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, The Clinical Investigator Training Program, Harvard-MIT Division of Health Sciences and Technology in collaboration with Pfizer Inc., The MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown

Gereon Nelles

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Department of Neurology, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

Judith D. Schaechter

The MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown

Jill D. Kaplan

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Department of Neurology, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

Seth P. Finklestein

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston

Bruce R. Rosen

The MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown

Functional brain imaging studies have provided insights into the processes related to motor recovery after stroke. The comparative value of different motor activation tasks for probing these processes has received limited study. We hypothesized that dif ferent hand motor tasks would activate the brain differently in controls, and that this would affect control-patient comparisons. Functional magnetic resonance imaging (MRI) was used to evaluate nine control subjects and seven patients with good recov ery after a left hemisphere hemiparetic stroke. The volume of activated brain in bilat eral sensorimotor cortex and four other motor regions was compared during each of three tasks performed by the right hand: index finger tapping, four-finger tapping, and squeezing. In control subjects, activation in left sensorimotor cortex was found to be significantly larger during squeezing as compared with index-finger tapping. When com paring control subjects with stroke patients, patients showed a larger volume of acti vation in right sensorimotor cortex during index-finger tapping but not with four-fin ger tapping or squeezing. In addition, patients also showed a trend toward larger activation volume than controls within left supplementary motor area during index- finger tapping but not during the other tasks. Motion artifact was more common with squeezing than with the tapping tasks. The choice of hand motor tasks used during brain mapping can influence findings in control subjects as well as the differences identified between controls and stroke patients. The results may be useful for future studies of motor recovery after stroke. Key Words: Stroke—Motor recovery—Functional MRI.

Neurorehabilitation and Neural Repair, Vol. 15, No. 1, 1-8 (2001)
DOI: 10.1177/154596830101500101


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. J. Kokotilo, J. J. Eng, M. J. McKeown, and L. A. Boyd Greater Activation of Secondary Motor Areas Is Related to Less Arm Use After Stroke Neurorehabil Neural Repair, January 1, 2010; 24(1): 78 - 87. [Abstract] [PDF]

				J. D. Schaechter and K. L. Perdue Enhanced Cortical Activation in the Contralesional Hemisphere of Chronic Stroke Patients in Response to Motor Skill Challenge Cereb Cortex, March 1, 2008; 18(3): 638 - 647. [Abstract] [Full Text] [PDF]

				L.-R. Zhao, H. H. Berra, W.-M. Duan, S. Singhal, J. Mehta, A. V. Apkarian, and J. A. Kessler Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats Stroke, October 1, 2007; 38(10): 2804 - 2811. [Abstract] [Full Text] [PDF]

				J. F. Toole, D. L. Flowers, J. H. Burdette, and J. R. Absher A Pianist's Recovery From Stroke Arch Neurol, August 1, 2007; 64(8): 1184 - 1188. [Abstract] [Full Text] [PDF]

				N. Shinoura, Y. Suzuki, R. Yamada, T. Kodama, M. Takahashi, and K. Yagi Restored Activation of Primary Motor Area from Motor Reorganization and Improved Motor Function after Brain Tumor Resection AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1275 - 1282. [Abstract] [Full Text] [PDF]

				L. M. Carey, D. F. Abbott, G. F. Egan, G. J. O'Keefe, G. D. Jackson, J. Bernhardt, and G. A. Donnan Evolution of Brain Activation with Good and Poor Motor Recovery after Stroke Neurorehabil Neural Repair, March 1, 2006; 20(1): 24 - 41. [Abstract] [PDF]

				C. Gerloff, K. Bushara, A. Sailer, E. M. Wassermann, R. Chen, T. Matsuoka, D. Waldvogel, G. F. Wittenberg, K. Ishii, L. G. Cohen, et al. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke Brain, March 1, 2006; 129(3): 791 - 808. [Abstract] [Full Text] [PDF]

				F. Binkofski and R. J. Seitz Modulation of the BOLD-response in early recovery from sensorimotor stroke Neurology, October 12, 2004; 63(7): 1223 - 1229. [Abstract] [Full Text] [PDF]

				C. M. Butefisch Plasticity in the Human Cerebral Cortex: Lessons from the Normal Brain and from Stroke Neuroscientist, April 1, 2004; 10(2): 163 - 173. [Abstract] [PDF]

				K. R. Crafton, A. N. Mark, and S. C. Cramer Improved understanding of cortical injury by incorporating measures of functional anatomy Brain, July 1, 2003; 126(7): 1650 - 1659. [Abstract] [Full Text] [PDF]

				C. Calautti and J.-C. Baron Functional Neuroimaging Studies of Motor Recovery After Stroke in Adults: A Review Stroke, June 1, 2003; 34(6): 1553 - 1566. [Abstract] [Full Text] [PDF]

				B. H. Dobkin Editorial Comment--Functional MRI: A Potential Physiologic Indicator for Stroke Rehabilitation Interventions Stroke, May 1, 2003; 34 (5): e26 - e28. [Full Text]

				J. D. Schaechter, E. Kraft, T. S. Hilliard, R. M. Dijkhuizen, T. Benner, S. P. Finklestein, B. R. Rosen, and S. C. Cramer Motor Recovery and Cortical Reorganization after Constraint-Induced Movement Therapy in Stroke Patients: A Preliminary Study Neurorehabil Neural Repair, December 1, 2002; 16(4): 326 - 338. [Abstract] [PDF]