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Neurorehabilitation and Neural Repair
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Effects of Temperature in Multiple Sclerosis: A Review of the Literature

Karl Syndulko

Neurology & Research Services, VA Medical Center-West Los Angeles, Department of Neurology, UCLA School of Medicine, Los Angeles, CA

Mehdi Jafari

Speech Pathology (126), VA Medical Center-Long Beach, CA

Agata Woldanski

Neurology & Research Services, VA Medical Center-West Los Angeles

Robert W. Baumhefner

Neurology & Research Services, VA Medical Center-West Los Angeles, Department of Neurology, UCLA School of Medicine, Los Angeles, CA

Wallace W. Tourtellotte

Neurology & Research Services, VA Medical Center-West Los Angeles, Department of Neurology, UCLA School of Medicine, Los Angeles, CA

A review of the literature indicates that up to 80% of multiple sclerosis (MS) patients report worsening of symptoms with elevated body temperature; there are also anecdo tal reports of amelioration or improvement in some signs and symptoms of MS with low ering of core temperature. This paper reviews the possible physiological basis for tem perature effects in multiple sclerosis and discusses clinical trial design issues for objective evaluation of the therapeutic use of cooling in the symptomatic management of MS, cooling. garments, and core temperature measurement.

Key Words: Key Words: Multiple sclerosis— Nerve conduction—Cooling—Temperature—Treatment—Cooling garment.

Neurorehabilitation and Neural Repair, Vol. 10, No. 1, 23-34 (1996)
DOI: 10.1177/154596839601000104
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